Changing epidemiology and decreased mortality associated with Carbapenem-resistant Gram-negative bacteria from 2000 – 2017

Carbapenem-resistant Gram-negative bacteria (CRGNB) continue to present a global healthcare crisis.

Patients from whom CRGNB were isolated between 2000 and 2017 were included in the study. Carbapenem resistance was defined by the most recent breakpoints and applied across the study period. Patient demographics, clinical characteristics, and outcomes were retrieved from the electronic health record. 

CRGNB emerged in waves over time causing high rates of mortality. Despite increasing rates of CRGNB, overall patient outcomes have improved suggesting that recognition and novel therapeutics have made a major impact.